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The first histamine intoxication was reported in sailors some centuries ago, but it was not until that publications began to describe the relationship between histamine and intoxication symptoms [ 92223 ].

In the s, the WHO recommended using the term histamine poisoning or intoxication, as the condition could be caused by the consumption of other fish species, as well as other foods [ 2 ]. The symptomatology associated with histamine intoxication is closely related to the different physiological actions of histamine in the organism.

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The main symptoms are neurological, gastrointestinal, dermatological and respiratory, notably rash, erythema, sweating, nausea, vomiting, diarrhoea, a sensation of burning in the mouth, swelling of tongue and face, sugar intolerance, respiratory distress, palpitations and hypotension [ 41521 ]. Symptoms are generally mild, appearing 30 minutes after ingestion and disappearing within 24 hours [ 41024 ].

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On rare occasions, they can be more severe and require medical attention [ 34 ]. The severity or type of reaction depends on the amount of histamine in the plasma. The similarity between the described symptomatology and that of allergic reactions can lead to an incorrect diagnosis.

  1. Что, если твои крохотные роботы забрели в очень важное место, в гнездо или храм октопауков.
  2. Millions are affected by lactose intolerance in Hungary | Trademagazin

Intoxication may be distinguished from a food allergy by taking into account the absence of an allergy history and its occurrence in an outbreak involving more than one patient over a short period of time after the consumption of foods with a high histamine load [ 9 ]. For a differential diagnosis, the concentration of serum tryptase measured within 1—2 hours of the onset of symptoms can also be helpful.

In food allergy, the activity of serum tryptase increases, whereas in histamine intoxication it should remain within normal physiological values [ 1525 ].

Дело происходило в зоопарке октопауков сразу же после появления на свет мирмикотов, вылупившихся из манно-дынь, которые Ричард доставил из Нью-Йорка. Невзирая на четкость, Николь не следила за ними пристально. Она по-прежнему думала о Ричарде. "После пробуждения я еще не позволяла себе скорбеть о твоем уходе, потому что не хотела обнаруживать слабость.

Moreover, intoxication may be confirmed by elevated histamine levels in the suspected implicated food [ 1 ].

This disorder is not so widely known as histamine intoxication, since the first reference regarding histaminosis or histamine intolerance dates fromand most of the studies have appeared during the last 15 years [ 28 ].

DAO enzyme deficiency may have a genetic aetiology.

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A significant relationship has been found between lower DAO activity and the presence of different single-nucleotide polymorphisms SNPs in the AOC1 gene located on chromosome 7 7q The secretion of DAO may also be inhibited by certain pathologies, especially inflammatory sugar intolerance diseases, and also by the action of drugs acetylcysteine, clavulanic acid, metoclopramide, verapamil, etc.

Individuals with histamine intolerance due to DAO deficiency may suffer symptoms similar to those of intoxication, but they appear after a lower histamine intake. The diagnosis is based on the presentation of at least two clinical symptoms, which go into remission when a low-histamine diet is adopted always after ruling out positive results for food allergy [ 1942 ].

Individuals with histamine intolerance can also be identified by determining serum DAO activity, although evidence for the usefulness of this analysis cukorbetegség elkerülése still scarce and inconclusive [ 2734364344 ].

Dose-response data from food histamine are scant [ 24 ]. According to sugar intolerance studies in healthy volunteers, histamine was found to trigger intoxication symptoms at levels of 75— mg when administered with food fish or non-alcoholic drinks [ 1 ]. When histamine was administered with alcoholic beverages, levels of 0.

Wantke et al. On the other hand, when mg of histamine was introduced directly into the duodenum not transported by foodsymptoms appeared in patients diagnosed with chronic urticaria but not in healthy volunteers [ 1 ].

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The majority of histamine poisoning outbreaks described in the literature occurred after the consumption of high amounts of histamine, mainly in fish [ 1 ]. Due to the lack of consensus to establish a threshold toxic dose for histamine intoxication, some authors have proposed some safe levels [ 34 ]. The same authors, however, pointed out that the accuracy of their calculation was limited by an incomplete understanding of histamine intoxication.

Later, Rauscher-Gabernig et al.

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A safe level of histamine intake for intolerant individuals is not proposed in any of the studies on this disorder. The only recommendation available is from EFSA, which carried out a risk assessment sugar intolerance href="">diabétesz kezelésére eltávolítási biogenic amine formation in fermented products and concluded that only foods with histamine levels below detectable limits can be considered safe for intolerant patients [ 1 ].

An impaired enzymatic activity may have a genetic explanation or be caused by intestinal sugar intolerance or the action of drugs with an inhibitory effect [ 151920 ]. In this context, the most studied enzyme is DAO. The enhanced sensitivity of women to histamine in certain physiological states, such as in the premenstrual period, is attributed to a reduced DAO activity [ 55 ].

Conversely, an increase in DAO production of up to fold has been reported during pregnancy, accompanied by a remission of certain symptoms related to histamine intolerance [ 56 ].

Therefore, from the metabolic point of view, there is inter- as well as intra-individual variation in sensitivity. The toxicity of histamine may be enhanced by dietary components, such as other biogenic amines or alcohol.

Putrescine, cadaverine, tyramine and spermidine are biogenic amines usually found together with histamine in food and likewise are DAO substrates. Due to competition for intestinal mucin attachment sites and metabolisation, the ingestion of high quantities of these other amines may potentiate the adverse effects of histamine [ 1101554 ]. This effect has been demonstrated in amines sugar intolerance as putrescine, cadaverine and tyramine, sugar intolerance others, in both sugar intolerance vitro and animal studies [ 111 ].

These amines were found to exert an inhibitory effect on histamine metabolism when present at levels 4—5 times higher than that of histamine [ 11 sugar intolerance. This potentiation mechanism could explain why symptoms do not appear when histamine is administered intravenously and yet are triggered when the same amounts of histamine are consumed in foods containing other amines [ 4 ]. Alcohol and its metabolite acetaldehyde can also have a potentiating effect.

Competition for the ALDH enzyme, which is involved in the metabolism of both alcohol and histamine, results in an accumulation of histamine [ 112 ]. A total of outbreaks were reported in — by different EU member states according to the EFSA reports on food-borne outbreaks [ 57 ].

Histamine and Other Biogenic Amines in Food. From Scombroid Poisoning to Histamine Intolerance

In of the outbreaks, the food responsible was determined with strong evidence, involving more than cases of which were hospitalised Figure 3. No deaths due to histamine intoxication were reported during this period. According to these data, there is no clear declining trend in the incidence of histamine intoxication in recent years, in contrast with other types of food poisoning Figure 3. Figure 3. Assessment of the incidence of histamine intoxication in EU countries during the — [ 57 ].

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On the other hand, according sugar intolerance information extracted from the Rapid Alert System for Food and Feed RASFFthere was a clear rise in notification of histamine intoxication cases linked to tuna consumption during —, with a particularly sharp increase in [ 57 ]. In MaySpain and France reported a high incidence of histamine intoxication after the consumption of yellowfin tuna from Spain.

Additional cases may have arisen in other countries that imported this food product. More than people in Spain and more than 40 in France were affected after consuming tuna that was allegedly treated with a vegetable extract to alter the colour and enhance display freshness [ 58 ].

The modification of colour may mask spoilage responsible for the production of histamine and other biogenic amines. The overall exposure to dietary histamine is difficult to estimate due to its multiple potential sources and variable concentration.

Ричард улыбнулся.

Figure 4which shows the distribution of histamine contents in different foods retailed in Spain, reflects this characteristic high variability, both among different food categories and within the same sugar intolerance. Figure 4. Fresh fish and fishery products usually do not contain histamine or only low levels [ 59 ]. As shown in Figure 4in most of the Spanish retail fish samples reported by Bover-Cid et al.

Notably, when freshness is lost, in addition to high amounts of histamine, other amines related to the decarboxylase activity of spoilage bacteria, such as cadaverine and putrescine, also frequently accumulate.

In fresh, cooked or cured meat, as in fish, no histamine occurrence is expected as long as freshness and a proper hygienic status of the products or sugar intolerance processes are ensured [ 1360 ]. In contrast, fermented foods are susceptible to accumulating large amounts of histamine [ 13561 ]. In fermented beverages e.

Sugar intolerance occurrence of putrescine and cadaverine is also quite common but at lower and more variable concentrations than tyramine. Among foods of plant origin, only some vegetables usually show significant levels of histamine, such as spinach, tomato and eggplant [ 13 ].

In these products low levels of histamine may have a physiological origin, but undesirable microbial enzymatic activity during storage can lead to the accumulation of high levels [ 1362 ]. Lavizzari et al. Histamine formation in this type of vegetables was attributed to the activity of some Gram-negative bacteria, mainly belonging to Enterobacteriaceae and Pseudomonadaceae groups, as their growth is favoured by the relatively high pH of spinach. Asparagus, pumpkin, chard and avocado rarely contain histamine and at very low levels [ 13 ].

Other types of frequently consumed foods, such as cereals, milk, yoghurt and eggs, do not show significant contents of histamine or any other biogenic amine [ 3 ]. In addition to food content, another fundamental issue when assessing exposure to histamine is the actual consumption of food by the population.

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Food consumption data need to be as representative as possible, with sources such as the a cukorbetegség kezelésének új módszerei recent national dietary surveys.

Likewise, in an assessment of the dietary histamine exposure of Austrian consumers, it was concluded that tuna fish and some fermented products cheese and sauerkraut were the top contributors to the total histamine intake [ 24 ].

According to this study, a typical meal with fish as a main dish could contribute from 2. Recently, Latorre-Moratalla et al.

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The larger serving size of fish products, together with the extremely high histamine contents arising from hygienic defects in their conservation or manufacturing processes, could explain why these foods contribute more to histamine exposure than others, such as cheese or dry-fermented sausages, which a priori have higher average histamine contents. This could also explain why fish and fishery products inzulinrezisztencia első jelei the predominant cause of histamine intoxication.

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However, a qualitative approach, taking into account the limited data available, suggests that the risk of suffering histamine intoxication is relatively low, since exposure exceeds the safety limit on very few occasions. However, it is stressed that this upper limit may be exceeded by the consumption of more than one food item with high histamine content during the same meal.