Alleviation of pain in painful diabetic neuropathy

Diabetic neuropathy mechanisms emerging treatments and subtypes, AZ INTÉZET KÖZLEMÉNYEI

Developmental Biology Laboratory — Imre Oláh. Molecular Biology Laboratory — Péter Enyedi.

Clinical Cardiovascular Laboratory — Márk Kollai. Laboratory of Tissue Engineering — Zsombor Lacza. Phagocyte Research Group diabetic neuropathy mechanisms emerging treatments and subtypes Erzsébet Ligeti. Inflammation Research Unit — Attila Mócsai. Laboratory of Vascular Physiology — Emil Monos. Laboratory of Cerebrovascular Research — Péter Sándor. Laboratory of Molecular Endocrinology — András Spät. Signal Transduction Laboratory — László Buday.

Chaperone and Network Group — Péter Csermely. Laboratory of Molecular Endocrinology — László Hunyady. Hemostasis Group — Raymund Machovich. Laboratory of Cell Biology — Zoltán Nagy.

National Angioedema Center — Henriette Farkas. Immunogenomics and Immunomics — András Falus. László Tretter, M. Clinical Genomics Unit — Csaba Szalai.

diabetic neuropathy mechanisms emerging treatments and subtypes

Reproductive Neuroendocrinology Laboratory — Ida Gerendai. Neuroendocrine Research Laboratory — Béla Halász. Immunohistological Laboratory — Katalin Köves.

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Neurochemical Research Unit — Kálmán Magyar. Clinical Neurophysiology Laboratory — Imre Szirmai. Gastroenterological Research Laboratory — Klára Gyires. Biochemical Pharmacology Unit — Kornélia Tekes.

Stability Research Group — Romána Zelkó. Salivary Research Laboratory — Tivadar Zelles. Molecular Genetic Unit — György Fekete. Neuropathy Research Group — Péter Kempler.

diabetic neuropathy mechanisms emerging treatments and subtypes

Clinical Research Laboratory — Péter Lakatos. Endocrinological Research Group — Károly Rácz.

Hepatology Unit — Ferenc Szalay. Pediatric Research Group — Tivadar Tulassay. Proteoglycan Research Group — Ilona Kovalszky. Molecular Therapy Laboratory — István Peták. Division of Assisted Reproduction — János Urbancsek.

diabetic neuropathy mechanisms emerging treatments and subtypes

Research Laboratory of Biomechanics — József Tihanyi. Miscellaneous Heart Center — Béla Merkely. Biochemical Research Group — Anna Blázovics.

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Sleep Medicine Unit — Márta Novák. Photocarcinogenesis, Photodermatology Unit — Norbert Wikonkál. The consortium also includes Richter Gedeon Ltd. Semmelweis University is also among the leading universities in Hungary regarding the number of research papers published in high quality international journals. I sincerely hope that this review is a reliable indicator of the high standard research activity at Semmelweis Universityanditwillsucceedinitsaimatpromotingdevelopment of inter-disciplinary teamwork.

Budapest, The mission of this booklet is to provide an overview on the research laboratories of highest merit at Semmelweis University and to offer an opportunity for establishing new scientific co-operation on the field of various disciplines.

diabetic neuropathy mechanisms emerging treatments and subtypes

This review can enhance the efficiency of joint efforts between research groups on an international level, thus offering multiply strength of fruitful scientific collaboration and grant application. Research projects in the preclinical and clinical departments are supported by both Hungarian and international programs. Contract research sponsored by pharmaceutical companies is also an important part of scientific activity.

Selected research groups are supported jointly by the University and the Hungarian Academy of Sciences. Our University is one of the recognized members of a vast network of biomedical science; it is the site where academy Tivadar Tulassay Rector of Semmelweis University Recent publications: Balogh, Zs. Reiniger, L.

Leukemia 20 6 : — Bognár, A. Leukemia 19 9 : — Bödör, Cs. Timár, B. Leukemia 18 2 : — Technicians: Adrienne Bárányné Pallag, Linda Deák, Anikó Lengyel Molecular basis of B-cell lymphoma development and progression The research activities of the group are centered around the molecular mechanisms underlying the development and progression of B-cell non-Hodgkin lymphomas, especially folicular lymphoma and chronic lymphocytic leukemia CLL.

Using extensive mutation profiling of different genes, including IgVH, BCL-6, BCL-2 we have characterized the clonal evolution and transformation of these lymphoma entities. These findings suggest that genetic instability may have a central role in the transformation process of indolent B-cell lymphomas.

Through mutational analysis of IgVH gene, we have shown that in follicular lymphoma, the early descendants of the original tumor clone and derivatives of diversified tumor clones may both invade the bone marrow, providing a direct evidence of clonal evolution.

Academic excellence in biomedical research at Semmelweis University 2008

Our current interests are aimed at finding the progenitor of the transformed tumor cell population in CLL, and we are also trying to reveal alternative molecular mechanisms responsible for the development of BCL-2 negative follicular lymphomas.

The first option is studied by the observation of the regeneration following surgical partial hepatectomy in experimental animals.

We pay special attention to the structural changes during the regenerative process. Alterations of the liver architecture is analyzed by laser scanning confocal and electron microscopy.

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A transgenic mouse line is maintained in our department, which overexpresses active TGF-β in the liver. These animals provide excellent opportunity to understand the role of this cytokine in the growth regulation of various liver processes including regeneration.

The stem cell driven regeneration is also studied in experimental animals and human specimens. The combination of partial hepatectomy with 2-acetaminofluorene treatment results in the synchronized, intense activation of the hepatic stem cell compartment.

Alleviation of pain in painful diabetic neuropathy

We study the anatomical location, phenotype and growth regulation of the stem cells in this experimental model. The so called ductular proliferation of the human liver may correspond a stem cell fed histological reaction. We try to understand the role of hepatic stem cells in different pathological liver processes by the analysis of ductular reactions with various origin. Recent publications: Dezsô, K. Szabó, E. Matrix Biol. Paku, S. Cancer — Hepatology — Professor Key words: liver stem cell regeneration carcinogenesis The Developmental Biology Laboratory was set up in Before this date the major research interest of the lab was immune morphology of the avian primary lymphoid organs, such as bursa of Fabricius and thymus, which are responsible for the B and T cell development, respectively.

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While the immunologists interested in the phenotypic and functional maturation of T and B cells, the morphologists turned to the early development of these organs.

More than ten years ago it was an intellectual challenge to study the developmental biology of these organs which was enlarged by the development of the spleen and gutassociated lymphoid tissue GALT.

Diabetic Neuropathy

During the last decade, in the short history of the Developmental Biology Laboratory young scientists, student research associates, graduate students and postdocs create a living, active research group with international reputation. Complex research work includes morphological methods light and electron microscopy, confocal microscopy, immunocytochemistrycell diabetic neuropathy mechanisms emerging treatments and subtypes organ culturing, monclonal antibody production, embryo microsurgery transplantation, ablation, recombination of organ rudimentschimera and parabiosis chick and quail.

The main research interest of the lab is the development of the lymphoid organs, the epithelio-mesenchymal interactions and neural crest cell differentiation.

AZ INTÉZET KÖZLEMÉNYEI | Farmakológiai és Farmakoterápiás Intézet

Topics: Development of the bursa kábítószer-diabetes gyógyszer Fabricius, spleen and thymus; organogenesis of the mucosa-associated lymphoid tissue MALT ; differentiaton of the dendritic cells, in normal and pathological conditions; production of avian specific antibodies; hemopoietic stem cell colonization of primary and secondary lymphoid organs; development of the enteric nervous system; bone marrow-derived hemopoietic cells in the non-lymphoid organs; structure, phenotype, function.

Recent publications: Igyártó, B. Igyártó, B. Cell Tissue Res. Nagy, N. Gumati, M. Professor Key words: embryo avian lymphoid tissue dendritic cells embryo manipulation For decades the work team has been involved in studies on human and experimental liver pathology, virus-cell interactions and in particular, on chemical and viral hepatocarcinogenesis.

In foreign collaborations, they have participated in the identification of hepatitis C virus HCV components. They proved in vivo and in vitro the association of the HCV core with endoplasmic reticulum membranes and lipid droplets. The group has also been involved in studies related to the effect of HCV on lipid metabolism. In clinical collaboration, it has been demonstrated that HCV type 1b causes liver steatosis too, as in the case of HCV type 3a. The studies on liver fibrosis have resulted in the work team being among the first to observe and describe components characteristic to the early stages of fibrogenesis in human liver diseases, their latest detection has been that of matrilin 2 in both human and experimental liver tissues.

The role cukorbetegség jelei kezelés significance of different growth factors, as transforming growth factor α and β have been proved in several liver diseases, especially in chronic hepatitis and hepatocellular carcinoma HCC. Among the cell junction proteins, the work team has directed their focus on claudins, with a number of reports on the role of claudins in several tumors, including liver tumors.

Based on their results, some of the studied claudins may even serve as potential therapeutic targets. Recent publications: Szabó, E. Matrix Biology — Batmunkh, E. Human Pathology — Tátrai, P. Laboratory Investigations — Lódi, Cs. Modern Pathology — Tôkés, A. Breast Cancer Research 7: R—R András Kiss, Dr.